Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.

ABSTRACT: Successful implantation is associated with a unique spatial pattern of vascular remodeling, characterized by profound peripheral neovascularization surrounding a periembryo avascular niche. We hypothesized that hyaluronan controls the formation of this distinctive vascular pattern encompassing the embryo. This hypothesis was evaluated by genetic modification of hyaluronan metabolism, specifically targeted to embryonic trophoblast cells. The outcome of altered hyaluronan deposition on uterine vascular remodeling and postimplantation development were analyzed by MRI, detailed histological examinations, and RNA sequencing of uterine NK cells. Our experiments revealed that disruption of hyaluronan synthesis, as well as its increased cleavage at the embryonic niche, impaired implantation by ind

SUBMITTER: Hadas R 

PROVIDER: S-EPMC7710306 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature