Association of the sEH gene promoter polymorphisms and haplotypes with preeclampsia.

ABSTRACT:

Background

The epoxyeicosatrienoic acids (EETs) have antihypertensive, anti-inflammatory, and organ protective properties and their circulation levels are related to hypertension, diabetes mellitus, cardiovascular diseases, and preeclampsia. Soluble epoxide hydrolase (sEH) catalyses the degradation of EETs to less biologically active dihydroxyeicosatrienoic acids. Here, we sequenced the promoter region of EPHX2 to investigate the association between promoter sequence alterations that we thought to affect the expression levels of the enzyme and preeclampsia (PE).

Methods

Nucleotide sequencing of the promoter region of the EPHX2, spanning from position -671 to +30, was performed on 100 pregnant women with PE and, 20 or more weeks pregnant normotensive, healthy wo

SUBMITTER: Sarı I 

PROVIDER: S-EPMC7710375 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature