Deletion of the oligopeptide transporter Lmo2193 decreases the virulence of Listeria monocytogenes.

ABSTRACT:

Background

Listeria monocytogenes is a gram-positive bacterium that causes listeriosis mainly in immunocompromised hosts. It can also cause foodborne outbreaks and has the ability to adapt to various environments. Peptide uptake in gram-positive bacteria is enabled by oligopeptide permeases (Opp) in a process that depends on ATP hydrolysis by OppD and F. Previously a putative protein Lmo2193 was predicted to be OppD, but little is known about the role of OppD in major processes of L. monocytogenes, such as growth, virulence, and biofilm formation.

Objectives

To determine whether the virulence traits of L. monocytogenes are related to OppD.

Methods

In this study, lmo2193 gene deletion and complementation strains of L. monocytogenes we

SUBMITTER: Li H 

PROVIDER: S-EPMC7710461 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature