Trajectories of Structural Disease Progression in Knee Osteoarthritis.

ABSTRACT:

Objective

Knee osteoarthritis (OA) is a heterogeneous disease, with most patients experiencing slow disease progression and some with rapid deterioration. We aimed to identify groups of patients with symptomatic knee OA experiencing rapid structural progression.

Methods

We selected participants from the Osteoarthritis Initiative with baseline Kellgren/Lawrence (K/L) grades 1-3 and knee pain, and with joint space width (JSW) on fixed-flexion knee radiographs assessed at baseline and with ≥1 follow-up over 8 years. We used latent class growth analysis to identify subgroups of JSW progression, jointly modeling time to knee replacement (KR) to account for potential informative dropouts. After identifying trajectories, we used logistic regression to assess the association between

SUBMITTER: Collins JE 

PROVIDER: S-EPMC7710564 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature