Replication and Genetic Risk Score Analysis for Pancreatic Cancer in a Diverse Multiethnic Population.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have identified several SNPs associated with pancreatic cancer. No studies yet have attempted to replicate these SNPs in US minority populations. We aimed to replicate the associations of 31 GWAS-identified SNPs with pancreatic cancer and build and test a polygenic risk score (PRS) for pancreatic cancer in an ethnically diverse population.

Methods

We evaluated 31 risk variants in the Multiethnic Cohort and the Southern Community Cohort Study. We included 691 pancreatic ductal adenocarcinoma (PDAC) cases and 13,778 controls from African-American, Japanese-American, Latino, Native Hawaiian, and white participants. We tested the association between each SNP and PDAC, established a PRS using the 31 SNPs, and tested the associatio

SUBMITTER: Bogumil D 

PROVIDER: S-EPMC7710597 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature