Glucosamine and Chondroitin Supplements and Risk of Colorectal Adenoma and Serrated Polyp.

ABSTRACT:

Background

Studies have shown an inverse association between use of glucosamine and chondroitin supplements and colorectal cancer risk. However, the association with the precursor lesion, colorectal adenoma and serrated polyp, has not been examined.

Methods

Analyses include 43,163 persons from the Nurses' Health Study (NHS), Health Professionals Follow-up Study (HPFS), and NHS2 who reported on glucosamine/chondroitin use in 2002 and who subsequently underwent ≥1 lower gastrointestinal endoscopy. By 2012, 5,715 conventional (2,016 high-risk) adenomas were detected, as were 4,954 serrated polyps. Multivariable logistic regression for clustered data was used to calculate OR and 95% confidence intervals (CI).

Results

Glucosamine/chondroitin use was inversely associated wi

SUBMITTER: Lee DH 

PROVIDER: S-EPMC7710617 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature