A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.

ABSTRACT: DNA 5-hydroxymethylcytosine (5hmC) modification is known to be associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development and in human diseases. However, the lack of genome-wide 5hmC profiles in different human tissue types impedes drawing generalized conclusions about how 5hmC is implicated in transcription activity and tissue specificity. To meet this need, we describe the development of a 5hmC tissue map by characterizing the genomic distributions of 5hmC in 19 human tissues derived from ten organ systems. Subsequent sequencing results enabled the identification of genome-wide 5hmC distributions that uniquely separates samples by tissue type. Further comparison of the 5hmC profiles with transcriptomes a

SUBMITTER: Cui XL 

PROVIDER: S-EPMC7710742 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature