Glucose Uptake and Insulin Response in Tissue-engineered Human Skeletal Muscle.

ABSTRACT:

Background

Tissue-engineered muscles ("myobundles") offer a promising platform for developing a human in vitro model of healthy and diseased muscle for drug development and testing. Compared to traditional monolayer cultures, myobundles better model the three-dimensional structure of native skeletal muscle and are amenable to diverse functional measures to monitor the muscle health and drug response. Characterizing the metabolic function of human myobundles is of particular interest to enable their utilization in mechanistic studies of human metabolic diseases, identification of related drug targets, and systematic studies of drug safety and efficacy.

Methods

To this end, we studied glucose uptake and insulin responsiveness in human tissue-engineered skeletal muscle myobundl

SUBMITTER: Kondash ME 

PROVIDER: S-EPMC7710786 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature