The Potential Significance of ABO Genotyping for Donor Selection in Kidney Transplantation.

ABSTRACT:

Background

The ABO blood group system is clinically important in kidney transplantation, but ABO genotyping fails to attract sufficient attention in some countries and regions. We identified one case of early graft dysfunction due to an ABO genotype mismatch. Here, we performed ABO genotyping in blood samples, analyzed grouping discrepancies, and investigated the weak A subgroup frequency in kidney transplantation candidates.

Methods

Blood samples from 302 uremic patients with grouping discrepancies and 356 uremic patients with type A blood were analyzed using standard serologic serotyping techniques. The ABO genotypes and alleles were analyzed by polymerase chain reaction sequence-specific primer (PCR-SSP) and sequence-based typing (PCR-SBT).

Results

All 302 uremic p

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7710857 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature