The independent and combined effects of selected risk factors and Arg399Gln XRCC1 polymorphism in the risk of colorectal cancer among an Iranian population.

ABSTRACT: Background: Several environmental and genetic factors have contributed to the development of colorectal cancer (CRC). We aimed to investigate the independent and combined effects of some selected risk factors and Arg399Gln XRCC1 polymorphism on CRC. Methods: A total of 180 patients with CRC and 160 healthy individuals who were matched for sex, age, and place of residence (Northeast of Iran) participated in this case-control study. Before collecting blood samples and filling out questionnaires, a written consent form was obtained from all participants. Genotypes were determined by RFLP-PCR. The comparison of genotype and allele frequencies was performed using p value based on the results of chi-square test. The odds ratios (OR) and 95% confidence intervals (CI) were calculated

SUBMITTER: Mehrzad J 

PROVIDER: S-EPMC7711031 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature