Levels of early-childhood behavioral inhibition predict distinct neurodevelopmental pathways to pediatric anxiety.

ABSTRACT:

Background

Anxiety symptoms gradually emerge during childhood and adolescence. Individual differences in behavioral inhibition (BI), an early-childhood temperament, may shape developmental paths through which these symptoms arise. Cross-sectional research suggests that level of early-childhood BI moderates associations between later anxiety symptoms and threat-related amygdala-prefrontal cortex (PFC) circuitry function. However, no study has characterized these associations longitudinally. Here, we tested whether level of early-childhood BI predicts distinct evolving associations between amygdala-PFC function and anxiety symptoms across development.

Methods

Eighty-seven children previously assessed for BI level in early childhood provided data at ages 10 and/or 13 years, con

SUBMITTER: Abend R 

PROVIDER: S-EPMC7711072 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature