Association of the Serotonin 2A Receptor rs6311 Polymorphism with Diurnal Preference in Koreans.

ABSTRACT:

Objective

Evidence for the association between circadian rhythm delay and depression is accumulating. Genetic studies have shown that certain polymorphisms in circadian genes are potential genetic markers of diurnal preference. Along with circadian genes, there is a growing interest in other genetic effects on circadian rhythms. This study evaluated whether the HTR2A rs6311 (-1438C/T) polymorphism is associated with diurnal preference in a Korean population.

Methods

A total of 510 healthy subjects were included in this study. All subjects were genotyped for the HTR2A rs6311 polymorphism and they completed the Korean version of the composite scale of morningness (CSM).

Results

The C allele carriers (C/C+C/T) showed significantly higher CSM scores compared to C allele n

SUBMITTER: Yeom JW 

PROVIDER: S-EPMC7711123 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature