BPI and KIR6.1 as significant hub genes for vein graft restenosis.

ABSTRACT:

Background

Vein graft restenosis (VGR), which appears to be caused by dyslipidemia following vascular transplantation, seriously affects the prognosis and long-term quality of life of patients.

Methods

This study analyzed the genetic data of restenosis (VGR group) and non-stenosis (control group) vessels from patients with coronary heart disease post-vascular transplantation and identified hub genes that might be responsible for its occurrence. GSE110398 was downloaded from the Gene Expression Omnibus database. A repeatability test for the GSE110398 dataset was performed using R language. This included the identification of differentially expressed genes (DEGs), enrichment analysis via Metascape software, pathway enrichment analysis, and construction of a protein-protein int

SUBMITTER: Bai YP 

PROVIDER: S-EPMC7711236 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature