Class IA PI3K inhibition inhibits cell growth and proliferation in mantle cell lymphoma.

ABSTRACT:

Background/aims

Constitutive activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin signaling pathway preferentially occurs in aggressive blastoid variants of mantle cell lymphoma (MCL) and is implicated in the pathogenesis of this disease. In this study, we investigated the role of PI3K isoforms on proliferation of aggressive MCL cells.

Methods

The changes in cell viability, cell cycle distribution and apoptosis induction by the PI3K isoform-selective inhibitors were evaluated. The molecular basis underlying the effects of the specific inhibition of PI3K isoforms was investigated by Western blot analysis.

Results

Our results demonstrated that a class IA PI3K isoform is most commonly involved in the constitutive activation of Akt in a

SUBMITTER: Tabe Y 

PROVIDER: S-EPMC7711304 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature