Trajectory of Unawareness of Memory Decline in Individuals With Autosomal Dominant Alzheimer Disease.

ABSTRACT:

Importance

Recent studies have suggested that unawareness, or anosognosia, of memory decline is present in predementia stages of Alzheimer disease (AD) and may serve as an early symptomatic indicator of AD.

Objective

To investigate the evolution of anosognosia of memory decline in individuals who carry the PSEN1 E280A variant for autosomal dominant AD compared with family members who do not carry the variant.

Design, setting, and participants

This cohort study investigated a total of 2379 members of a Colombian kindred with autosomal dominant AD who were part of the Alzheimer's Prevention Initiative Registry. Assessments were completed at the University of Antioquia, Colombia, with data collected between January 1, 2000, and July 31, 2019.

Main outcomes and measure

SUBMITTER: Vannini P 

PROVIDER: S-EPMC7711319 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature