Liquid biopsy is a valuable tool in the diagnosis and management of lung cancer.

ABSTRACT: Liquid biopsy refers to the use of various body fluids to test for circulating biological elements derived from the tumor. Liquid biopsy has taken on an increasingly important role in lung cancer diagnosis, molecular characterization, surveillance, monitoring, and determining mechanisms of resistance. These assays can utilize various sources of cell-free DNA (cfDNA) including blood, pleural fluid, urine, and others to detect tumor associated alterations. With the increasing power of next-generation sequencing technologies and the development of assays such as digital droplet PCR, rare tumor alleles can be detected in cfDNA to determine key characteristics of the tumor. Current assays, while effective, are still challenged by limited sensitivity and capacity to single genes or small panels

SUBMITTER: Cecchini MJ 

PROVIDER: S-EPMC7711358 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature