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Changing paradigm in advanced and metastatic non-small cell lung cancer.

ABSTRACT: Lung cancer is the most common cancer worldwide. Approximately 18% of all deaths related to cancer are associated with lung cancer. Management of non-small cell lung cancer (NSCLC) has been changing rapidly in last few years. For patients with unresectable non-metastatic disease, maintenance durvalumab is now given after offering chemo-radiation concurrently based on the result from the PACIFIC trial. Management of metastatic disease greatly depends on the status of sensitizing driver mutation and PD-L1 level of the tumor cells. In this review article, we will summarize the outcome of various clinical trials and will provide the most up-to-date information on the management of patients with advanced and metastatic NSCLC.

SUBMITTER: Uprety D

PROVIDER: S-EPMC7711369 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Changing paradigm in advanced and metastatic non-small cell lung cancer.

Uprety Dipesh D Parikh Kaushal K Sawkar Anita A Dimou Anastasios A Leventakos Konstantinos K

Journal of thoracic disease 20201101 11

Lung cancer is the most common cancer worldwide. Approximately 18% of all deaths related to cancer are associated with lung cancer. Management of non-small cell lung cancer (NSCLC) has been changing rapidly in last few years. For patients with unresectable non-metastatic disease, maintenance durvalumab is now given after offering chemo-radiation concurrently based on the result from the PACIFIC trial. Management of metastatic disease greatly depends on the status of sensitizing driver mutation a ...[more]

PMID: 33282404

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