Three tumor markers for improved efficacy in the management of patients with malignant pleural mesothelioma.

ABSTRACT:

Background

Evaluation of tumor markers may facilitate follow-up of malignant pleural mesothelioma (MPM). We aimed was to evaluate the value of tumor markers for monitoring and predicting recurrence in patients with MPM.

Methods

In total, 152 patients who underwent curative-intent surgery after induction chemotherapy for MPM between July 2004 and December 2017 were retrospectively reviewed. Preoperative and postoperative (≤3 months after surgery) levels of soluble mesothelin-related peptide (SMRP), cytokeratin 19 fragment (Cyfra21-1), and tissue polypeptide antigen (TPA) and rates of recurrence and non-recurrence were evaluated. Factors associated with recurrence-free survival (RFS) were assessed using the Kaplan-Meier method and Cox proportional hazards model.

Results

SUBMITTER: Nakamura A 

PROVIDER: S-EPMC7711396 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature