Changes in the Gut Microbiome after Galacto-Oligosaccharide Administration in Loperamide-Induced Constipation.

ABSTRACT: Unbalanced dietary habits and the consumption of high protein and instant foods cause an increase in constipation. Here, we evaluated the effects of galacto-oligosaccharide (GOS) on a rat model of loperamide-induced constipation by measuring various biological markers and cecal microbiota. The fecal water content and intestinal transit ratio significantly increased in the GOS-administered (GL and GH) groups than in the control group (p < 0.05, p < 0.01, and p < 0.001, respectively). The length of intestinal mucosa (p < 0.05 and p < 0.01, respectively) and area of crypt cells were (p < 0.01, both) significantly increased in the GOS-administered groups compared to the control group. The distribution of interstitial cells of Cajal, which is related to the intestinal movement, showed a signifi

SUBMITTER: Kim MG 

PROVIDER: S-EPMC7711924 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature