Shortening the Lipid A Acyl Chains of <i>Bordetella pertussis</i> Enables Depletion of Lipopolysaccharide Endotoxic Activity.

ABSTRACT: Whooping cough, or pertussis, is an acute respiratory infectious disease caused by the Gram-negative bacterium Bordetella pertussis. Whole-cell vaccines, which were introduced in the fifties of the previous century and proved to be effective, showed considerable reactogenicity and were replaced by subunit vaccines around the turn of the century. However, there is a considerable increase in the number of cases in industrialized countries. A possible strategy to improve vaccine-induced protection is the development of new, non-toxic, whole-cell pertussis vaccines. The reactogenicity of whole-cell pertussis vaccines is, to a large extent, derived from the lipid A moiety of the lipopolysaccharides (LPS) of the bacteria. Here, we engineered B. pertussis strains with altered lipid

SUBMITTER: Arenas J 

PROVIDER: S-EPMC7712016 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature