Predictive Role of Biopsy Based Biomarkers for Radiotherapy Treatment in Rectal Cancer.

ABSTRACT:

Background and purpose

Radiation therapy has long been contemplated as an important mode in the treatment of rectal cancer. However, there are few ideal tools available for clinicians to make a radiotherapy decision at the time of diagnosis for rectal cancer. The purpose of this study was to assess whether biomarkers expressed in the biopsy could help to choose the suitable therapy and provide predictive and/or prognostic information.

Experimental design

In total, 30 biomarkers were analyzed in 219 biopsy samples before treatment to discover the possibility of using them as an indicator for radiotherapy selection, diagnosis, survival and recurrence.

Results

Twenty-two biomarkers (COX2-RT, COX2-NonRT, etc.; 36.67%) had diagnostic value. For survival, four biomarkers (N

SUBMITTER: Wen Y 

PROVIDER: S-EPMC7712120 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature