Association of UBE3C Variants with Reduced Kidney Function in Patients with Diabetic Kidney Disease.

ABSTRACT: Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM) and the most common variant of end-stage renal disease (ESRD) globally. The economic burden of ESRD treatment with dialysis is substantial. The incidence and prevalence of ESRD in Taiwan remain the highest worldwide. Therefore, identifying genetic factors affecting kidney function would have valuable clinical implications. We performed microarray experiments and identified that ubiquitin protein ligase E3C (UBE3C) is differentially expressed in two DKD patient groups with extreme (low and high) urine protein-to-creatinine ratios. A follow-up genotyping study was performed in a larger group to investigate any specific variants of UBE3C associated with DKD. A to

SUBMITTER: Chen YC 

PROVIDER: S-EPMC7712123 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature