Epidemiological Impact of SARS-CoV-2 Vaccination: Mathematical Modeling Analyses.

ABSTRACT: This study aims to inform SARS-CoV-2 vaccine development/licensure/decision-making/implementation, using mathematical modeling, by determining key preferred vaccine product characteristics and associated population-level impacts of a vaccine eliciting long-term protection. A prophylactic vaccine with efficacy against acquisition (VE_S) ≥70% can eliminate the infection. A vaccine with VE_S <70% may still control the infection if it reduces infectiousness or infection duration among those vaccinated who acquire the infection, if it is supplemented with <20% reduction in contact rate, or if it is complemented with herd-immunity. At VE_S of 50%, the number of vaccinated persons needed to avert one infection is 2.4, and the number is 25.5 to av

SUBMITTER: Makhoul M 

PROVIDER: S-EPMC7712303 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature