An Overview of the Application of Systems Biology in an Understanding of Chronic Rhinosinusitis (CRS) Development.

ABSTRACT: Chronic rhinosinusitis (CRS) is an inflammatory disease of the paranasal sinuses. It is defined as the presence of a minimum of two out of four main symptoms such as hyposmia, facial pain, nasal blockage, and discharge, which last for 8-12 weeks. CRS significantly impairs a patient's quality of life. It needs special treatment mainly focusing on preventing local infection/inflammation with corticosteroid sprays or improving sinus drainage using nasal saline irrigation. When other treatments fail, endoscopic sinus surgery is considered an effective option. According to the state-of-the-art knowledge of CRS, there is more evidence suggesting that it is more of an inflammatory disease than an infectious one. This condition is also treated as a multifactorial inflammatory disorder as it may be

SUBMITTER: Michalik M 

PROVIDER: S-EPMC7712485 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature