Bone-Specific Metabolism of Dietary Polyphenols in Resorptive Bone Diseases.

ABSTRACT:

Scope

Curcumin prevents bone loss in resorptive bone diseases and inhibits osteoclast formation, a key process driving bone loss. Curcumin circulates as an inactive glucuronide that can be deconjugated in situ by bone's high β-glucuronidase (GUSB) content, forming the active aglycone. Because curcumin is a common remedy for musculoskeletal disease, effects of microenvironmental changes consequent to skeletal development or disease on bone curcumin metabolism are explored.

Methods and results

Across sexual/skeletal development or between sexes in C57BL/6 mice ingesting curcumin (500 mg kg^-1 ), bone curcumin metabolism and GUSB enzyme activity are unchanged, except for >twofold higher (p < 0.05) bone curcumin-glucuronide substrate levels in immature (4-6-week-old) m

SUBMITTER: Kunihiro AG 

PROVIDER: S-EPMC7712627 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature