Treatment of C3 Glomerulopathy in Adult Kidney Transplant Recipients: A Systematic Review.

ABSTRACT:

Background

C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative complement pathway dysregulation, is associated with a high rate of recurrence and graft loss after kidney transplantation (KTx). We aimed to assess the efficacy of different treatments for C3G recurrence after KTx.

Methods

Databases (MEDLINE, EMBASE, and Cochrane Database) were searched from inception through 3 May, 2019. Studies were included that reported outcomes of adult KTx recipients with C3G. Effect estimates from individual studies were combined using the random-effects, generic inverse variance method of DerSimonian and Laird., The protocol for this meta-analysis is registered with PROSPERO (no. CRD42019125718).

Results

Twelve studies (7 cohort studies and 5 case series) co

SUBMITTER: Gonzalez Suarez ML 

PROVIDER: S-EPMC7712822 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature