Comparative Genome Sequence Analyses of Geographic Samples of Aspergillus fumigatus-Relevance for Amphotericin B Resistance.

ABSTRACT: Amphotericin B (AMB) is a major fungicidal polyene agent that has a broad spectrum of action against invasive fungal infections. AMB is typically used as the last-line drug against serious and life-threatening infections when other drugs have failed to eliminate the fungal pathogens. Recently, AMB resistance in Aspergillus fumigatus has become more evident. For example, a high rate of AMB resistance (96%) was noted in the A. fumigatus population in Hamilton, Ontario, Canada. AMB-resistant strains have also been found in other countries. However, the mechanism of AMB resistance remains largely unknown. Here, we investigated the potential genes and mutations associated with AMB resistance using whole-genome sequences and examined AMB resistance distribution among genetic popula

SUBMITTER: Fan Y 

PROVIDER: S-EPMC7713013 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature