Exploring the effect of UV-C radiation on earthworm and understanding its genomic integrity in the context of H2AX expression.

ABSTRACT: Maintaining genomic stability is inevitable for organism survival and it is challenged by mutagenic agents, which include ultraviolet (UV) radiation. Whenever DNA damage occurs, it is sensed by DNA-repairing proteins and thereby performing the DNA-repair mechanism. Specifically, in response to DNA damage, H2AX is a key protein involved in initiating the DNA-repair processes. In this present study, we investigate the effect of UV-C on earthworm, Perionyx excavatus and analyzed the DNA-damage response. Briefly, we expose the worms to different doses of UV-C and find that worms are highly sensitive to UV-C. As a primary response, earthworms produce coelomic fluid followed by autotomy. However, tissue inflammation followed by death is observed when we expose worm to increased doses of UV-C. In

SUBMITTER: Subbiahanadar Chelladurai K 

PROVIDER: S-EPMC7713072 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature