Comprehensive analysis of cutaneous and uveal melanoma liver metastases.

ABSTRACT:

Background

The profound disparity in response to immune checkpoint blockade (ICB) by cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood. Therefore, we characterized metastases of CM and UM from the same metastatic site (liver), in order to dissect the potential underlying mechanism in differential response on ICB.

Methods

Tumor liver samples from CM (n=38) and UM (n=28) patients were analyzed at the genomic (whole exome sequencing), transcriptional (RNA sequencing) and protein (immunohistochemistry and GeoMx Digital Spatial Profiling) level.

Results

Comparison of CM and UM metastases from the same metastatic site revealed that, although originating from the same melanocyte lineage, CM and UM differed in somatic mutation profile, copy numbe

SUBMITTER: Hoefsmit EP 

PROVIDER: S-EPMC7713183 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature