Maternal metabolic profiling to assess fetal gestational age and predict preterm delivery: a two-centre retrospective cohort study in the US.

ABSTRACT:

Objectives

The aim of this study was to develop a single blood test that could determine gestational age and estimate the risk of preterm birth by measuring serum metabolites. We hypothesised that serial metabolic modelling of serum analytes throughout pregnancy could be used to describe fetal gestational age and project preterm birth with a high degree of precision.

Study design

A retrospective cohort study.

Setting

Two medical centres from the USA.

Participants

Thirty-six patients (20 full-term, 16 preterm) enrolled at Stanford University were used to develop gestational age and preterm birth risk algorithms, 22 patients (9 full-term, 13 preterm) enrolled at the University of Alabama were used to validate the algorithms.

Outcome measures

Maternal blood

SUBMITTER: Sylvester KG 

PROVIDER: S-EPMC7713207 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature