The efficacy of probiotics in management of recurrent aphthous stomatitis: a systematic review and meta-analysis.

ABSTRACT: There is currently a lack of effective drugs to cure recurrent aphthous stomatitis. This study aimed to evaluate the efficacy of probiotics alone or as an adjunct in recurrent aphthous stomatitis (RAS) patients. Seven randomized controlled trials (RCTs) were included, of which three were included in quantitative analysis. Of five studies evaluating the efficacy of probiotics alone compared with placebo or Oracure gel, two reported no significant difference in relieving oral pain, while probiotics exhibited a higher capacity for decreasing oral pain in the other three. A significant decrease in ulcer severity was found in one, while no significant difference was found in the other four. The remaining two studies demonstrated that probiotics, as an adjunct to steroids or anaesthetic antisept

SUBMITTER: Cheng B 

PROVIDER: S-EPMC7713296 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature