Deletion of the GAPDH gene contributes to genome stability in Saccharomyces cerevisiae.

ABSTRACT: Cellular metabolism is directly or indirectly associated with various cellular processes by producing a variety of metabolites. Metabolic alterations may cause adverse effects on cell viability. However, some alterations potentiate the rescue of the malfunction of the cell system. Here, we found that the alteration of glucose metabolism suppressed genome instability caused by the impairment of chromatin structure. Deletion of the TDH2 gene, which encodes glyceraldehyde 3-phospho dehydrogenase and is essential for glycolysis/gluconeogenesis, partially suppressed DNA damage sensitivity due to chromatin structure, which was persistently acetylated histone H3 on lysine 56 in cells with deletions of both HST3 and HST4, encoding NAD⁺-dependent deacetylases. tdh2 deletion also restored

SUBMITTER: Hanasaki M 

PROVIDER: S-EPMC7713361 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature