COVID-19: Understanding Inter-Individual Variability and Implications for Precision Medicine.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is characterized by heterogeneity in susceptibility to the disease and severity of illness. Understanding inter-individual variation has important implications for not only allocation of resources but also targeting patients for escalation of care, inclusion in clinical trials, and individualized medical therapy including vaccination. In addition to geographic location and social vulnerability, there are clear biological differences such as age, sex, race, presence of comorbidities, underlying genetic variation, and differential immune response that contribute to variability in disease manifestation. These differences may have implications for precision medicine. Specific examples include the observation that androgens regulate the expression of the enzy

SUBMITTER: Pereira NL 

PROVIDER: S-EPMC7713605 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature