Altered Gut Microbiota and Host Metabolite Profiles in Women With Human Immunodeficiency Virus.

ABSTRACT:

Background

Alterations in gut microbiota (GMB) and host metabolites have been noted in individuals with HIV. However, it remains unclear whether alterations in GMB and related functional groups contribute to disrupted host metabolite profiles in these individuals.

Methods

This study included 185 women (128 with longstanding HIV infection, 88% under antiretroviral therapy; and 57 women without HIV from the same geographic location with comparable characteristics). Stool samples were analyzed by 16S rRNA V4 region sequencing, and GMB function was inferred by PICRUSt. Plasma metabolomic profiling was performed using liquid chromatography-tandem mass spectrometry, and 133 metabolites (amino acids, biogenic amines, acylcarnitines, and lipids) were analyzed.

Results

Four pr

SUBMITTER: Wang Z 

PROVIDER: S-EPMC7713676 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature