Impact of Diabetes and Low Body Mass Index on Tuberculosis Treatment Outcomes.

ABSTRACT:

Background

Diabetes was identified as a tuberculosis (TB) risk factor mostly in retrospective studies with limited assessments of metabolic variables. The prospective Effects of Diabetes on Tuberculosis Severity study compared adults with pulmonary TB in Chennai, India, who were classified as having either diabetes or a normal glucose tolerance at enrollment.

Methods

Baseline TB severity, sputum conversion, and treatment outcomes (cure, failure, death, or loss to follow-up) were compared between groups with respect to glycemic status and body mass index (BMI).

Results

The cohort of 389 participants included 256 with diabetes and 133 with a normal glucose tolerance. Low BMIs (<18.5 kg/m2) were present in 99 (74.4%) of nondiabetic participants and 85 (33.2%) of those wi

SUBMITTER: Kornfeld H 

PROVIDER: S-EPMC7713690 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature