Association of education with Aβ burden in preclinical familial and sporadic Alzheimer disease.

ABSTRACT:

Objective

To determine whether years of education and the ε4 risk allele at APOE influence β-amyloid (Aβ) pathology similarly in asymptomatic individuals with a family history of sporadic Alzheimer disease (AD) and presymptomatic autosomal dominant AD mutation carriers.

Methods

We analyzed cross-sectional data from 106 asymptomatic individuals with a parental history of sporadic AD (PREVENT-AD cohort; age 67.28 ± 4.72 years) and 117 presymptomatic autosomal dominant AD mutation carriers (DIAN cohort; age 35.04 ± 9.43 years). All participants underwent structural MRI and Aβ-PET imaging. In each cohort we investigated the influence of years of education, APOE ε4 status, and their interaction on Aβ-PET.

Results

Asymptomatic individuals with a parental histo

SUBMITTER: Gonneaud J 

PROVIDER: S-EPMC7713743 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature