Multitracer model for staging cortical amyloid deposition using PET imaging.

ABSTRACT:

Objective

To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability.

Methods

Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 with Alzheimer disease [AD] dementia, 111 with non-AD dementia, and 28 with missing diagnosis) from 6 cohorts (European Medical Information Framework for AD, Alzheimer's and Family, Alzheimer's Biomarkers in Daily Practice, Amsterdam Dementia Cohort, Open Access Series of Imaging Studies [OASIS]-3, Alzheimer's Disease Neuroimaging Initiative [ADNI]) who underwent amyloid PET were retrospectively included; 1,049 individuals had follow-up scans. With application of dataset-specific cutoffs to global standard uptake value ratio (SUVr) values from 27 regions, s

SUBMITTER: Collij LE 

PROVIDER: S-EPMC7713745 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature