Apolipoprotein E genotype and in vivo amyloid burden in middle-aged Hispanics.

ABSTRACT:

Objective

To examine in vivo amyloid burden in relation to APOEε4 genotype in middle-aged Hispanics. We hypothesize higher amyloid levels among APOE ε4 carriers vs APOE ε4 noncarriers.

Methods

This is a cross-sectional study in a community-based sample of 249 middle-aged Hispanics in New York City who underwent a 3T brain MRI and PET with the amyloid radioligand ¹⁸F-florbetaben. APOE genotype was the primary exposure. The primary outcome was amyloid positivity. The secondary outcome was subthreshold amyloid levels examined as a continuous variable.

Results

APOE ε4 carriers (n = 85) had a higher frequency (15.3%) of amyloid positivity compared to APOE ε4 noncarriers (n = 164, 1.8%). In the subthreshold group of amylo

SUBMITTER: Palta P 

PROVIDER: S-EPMC7713748 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature