Familial aggregation of status epilepticus in generalized and focal epilepsies.

ABSTRACT:

Objective

To determine whether familial aggregation of status epilepticus (SE) occurs in a large cohort of familial common epilepsies.

Methods

We used the Epilepsy Phenome/Genome Project dataset, which consisted of 2,197 participants in 1,043 family units with ≥2 members having a common generalized or nonacquired focal epilepsy (NAFE). We identified participants with a history of traditionally defined SE (TSE) (seizures ≥30 minutes) and operationally defined SE (OSE) (seizures ≥10 minutes) by chart review. We assessed familial aggregation of TSE and OSE using χ² analysis and generalized estimating equations (GEE).

Results

One hundred fifty-five (7%) participants in 1,043 families had ≥1 episodes of TSE. Two hundred fifty (11%) had ≥1 episodes of OSE. In a χ

SUBMITTER: Weisenberg JLZ 

PROVIDER: S-EPMC7713751 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature