Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults.

ABSTRACT:

Objective

To determine the cognitive consequences of anticholinergic medications (aCH) in cognitively normal older adults as well as interactive effects of genetic and CSF Alzheimer disease (AD) risk factors.

Methods

A total of 688 cognitively normal participants from the Alzheimer's Disease Neuroimaging Initiative were evaluated (mean age 73.5 years, 49.6% female). Cox regression examined risk of progression to mild cognitive impairment (MCI) over a 10-year period and linear mixed effects models examined 3-year rates of decline in memory, executive function, and language as a function of aCH. Interactions with APOE ε4 genotype and CSF biomarker evidence of AD pathology were also assessed.

Results

aCH+ participants had increased risk of progression to MCI (haza

SUBMITTER: Weigand AJ 

PROVIDER: S-EPMC7713781 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature