Longitudinal expression changes are weak correlates of disease progression in Huntington's disease.

ABSTRACT: Huntington's disease is a severe but slowly progressive hereditary illness for which only symptomatic treatments are presently available. Clinical measures of disease progression are somewhat subjective and may require years to detect significant change. There is a clear need to identify more sensitive, objective and consistent measures to detect disease progression in Huntington's disease clinical trials. Whereas Huntington's disease demonstrates a robust and consistent gene expression signature in the brain, previous studies of blood cell RNAs have lacked concordance with clinical disease stage. Here we utilized longitudinally collected samples from a well-characterized cohort of control, Huntington's disease-at-risk and Huntington's disease subjects to evaluate the possible correlation

SUBMITTER: Mitchell CT 

PROVIDER: S-EPMC7713990 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature