Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents.

ABSTRACT:

Objectives

The discovery and development of TB drugs has met limited success, with two new drugs approved over the last 40 years. Part of the difficulty resides in the lack of well-established in vitro or in vivo targets of potency and physicochemical and pharmacokinetic parameters. In an attempt to benchmark and compare such properties for anti-TB agents, we have experimentally determined and compiled these parameters for 36 anti-TB compounds, using standardized and centralized assays, thus ensuring direct comparability across drugs and drug classes.

Methods

Potency parameters included growth inhibition, cidal activity against growing and non-growing bacteria and activity against intracellular mycobacteria. Pharmacokinetic parameters included basic physicochemical propertie

SUBMITTER: Lakshminarayana SB 

PROVIDER: S-EPMC7714050 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature