Clinical implications of differences between real world and clinical trial usage of left ventricular assist devices for end stage heart failure.

ABSTRACT:

Importance

Patient outcomes in heart failure clinical trials are generally better than those observed in real-world settings. This may be related to stricter inclusion and exclusion criteria in clinical trials.

Objective

We study sought to characterize the clinical implications of differences between patients in clinical trials and those in a real-world registry of patients receiving left ventricular assist devices (LVADs).

Design, setting, and participants

This retrospective cohort study included all patients in INTERMACS (the Interagency Registry for Mechanically Assisted Circulatory Support) who were implanted with an axial flow LVAD from 2010 to 2015 to allow for equivalent comparisons.

Main outcomes and measures

Differences in patient characteristics and 2

SUBMITTER: Mezzacappa C 

PROVIDER: S-EPMC7714148 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature