Inflammatory patterns in fixed airflow obstruction are dependent on the presence of asthma.

ABSTRACT:

Rationale

Fixed airflow obstruction (FAO) can complicate asthma. Inflammation is a proposed underlying mechanism.

Objective

Our aim in this cross-sectional investigation was to evaluate the blood leucocyte pattern and level of exhaled nitric oxide in asthmatics and non-asthmatics with or without FAO.

Methods

A total of 11,579 individuals aged ≥20 years from the US National Health and Nutrition Examination Survey were included. They were grouped as: controls without asthma and FAO (n = 9,935), asthmatics without FAO (n = 674), asthmatics with FAO (n = 180) and non-asthmatics with FAO (n = 790). FAO was defined as post-bronchodilator FEV1/FVC < lower limit of normal. Exhaled nitric oxide ≥ 25ppb, blood eosinophil levels ≥300 cells/μL, and blood neutrophil levels ≥5100 c

SUBMITTER: Mogensen I 

PROVIDER: S-EPMC7714172 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature