The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer.

ABSTRACT:

Background

The effects of diet in cancer, in general, and breast cancer in particular, are not well understood. Insulin inhibition in ketogenic, high fat diets, modulate downstream signaling molecules and are postulated to have therapeutic benefits. Obesity and diabetes have been associated with higher incidence of breast cancer. Addition of anti-cancer drugs together with diet is also not well studied.

Methods

Two diets, one ketogenic, the other standard mouse chow, were tested in a spontaneous breast cancer model in 34 mice. Subgroups of 3-9 mice were assigned, in which the diet were implemented either with or without added rapamycin, an mTOR inhibitor and potential anti-cancer drug.

Results

Blood glucose and insulin concentrations in mice ingesting the ketogenic di

SUBMITTER: Zou Y 

PROVIDER: S-EPMC7714189 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature