PolyFold: An interactive visual simulator for distance-based protein folding.

ABSTRACT: Recent advances in distance-based protein folding have led to a paradigm shift in protein structure prediction. Through sufficiently precise estimation of the inter-residue distance matrix for a protein sequence, it is now feasible to predict the correct folds for new proteins much more accurately than ever before. Despite the exciting progress, a dedicated visualization system that can dynamically capture the distance-based folding process is still lacking. Most molecular visualizers typically provide only a static view of a folded protein conformation, but do not capture the folding process. Even among the selected few graphical interfaces that do adopt a dynamic perspective, none of them are distance-based. Here we present PolyFold, an interactive visual simulator for dynamically captur

SUBMITTER: McGehee AJ 

PROVIDER: S-EPMC7714222 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature