Determining the effects of nanoparticulate air pollution on proteostasis in Caenorhabditis elegans.

ABSTRACT: The proteostasis network comprises the biochemical pathways that together maintain and regulate proper protein synthesis, transport, folding, and degradation. Many neurodegenerative diseases are characterized by a failure of the proteostasis network to sustain the health of the proteome, resulting in protein misfolding, aggregation, and, often, neurotoxicity. Although important advances have been made in recent years to identify genetic risk factors for neurodegenerative diseases, we still know relatively little about environmental risk factors such as air pollution. Exposure to nano-sized particulate air pollution, referred to herein as nanoparticulate matter (nPM), has been shown to trigger the accumulation of misfolded and oligomerized amyloid beta in mice. This suggests that the abilit

SUBMITTER: Green EH 

PROVIDER: S-EPMC7714337 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature