TST conversions and systemic interferon-gamma increase after methotrexate introduction in psoriasis patients.

ABSTRACT:

Background

Tuberculosis screening in psoriasis patients is complex due to the immunological alterations associated with psoriasis, the presence of comorbidities, and the effect of immunosuppressive treatment. However, it is not established whether the results of screening tests are affected by these factors in psoriasis patients.

Objectives

To determine whether there is a change in the results of the tuberculin skin test (TST) or the interferon-gamma release assay (IGRA) in psoriasis patients living in tuberculosis (TB)-endemic area after 12 weeks of methotrexate (MTX) treatment and to investigate the association of the test results with clinical and inflammatory markers.

Methods

Forty-five patients were selected for a prospective single-arm self-controlled study and

SUBMITTER: de Medeiros VLS 

PROVIDER: S-EPMC7714364 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature