Meta-analysis of the gut microbiota in predicting response to cancer immunotherapy in metastatic melanoma.

ABSTRACT: BACKGROUNDIdentifying factors conferring responses to therapy in cancer is critical to select the best treatment for patients. For immune checkpoint inhibition (ICI) therapy, mounting evidence suggests that the gut microbiome can determine patient treatment outcomes. However, the extent to which gut microbial features are applicable across different patient cohorts has not been extensively explored.METHODSWe performed a meta-analysis of 4 published shotgun metagenomic studies (Ntot = 130 patients) investigating differential microbiome composition and imputed metabolic function between responders and nonresponders to ICI.RESULTSOur analysis identified both known microbial features enriched in responders, such as Faecalibacterium as the prevailing taxa, as well as additional features, includ

SUBMITTER: Limeta A 

PROVIDER: S-EPMC7714408 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature