Comparative [¹⁸F]FDG and [¹⁸F]DPA714 PET imaging and time-dependent changes of brown adipose tissue in tumour-bearing mice.

ABSTRACT: Brown adipose tissue (BAT) is important in monitoring energy homeostasis and cancer cachexia. Different from white adipose tissue, BAT is characterized by the presence of a large number of mitochondria in adipocytes. Translocator protein 18 kDa (TSPO), a critical transporter, is expressed in the outer membrane of mitochondria. We speculated that [¹⁸F]DPA714, a specific TSPO tracer, may monitor BAT activity in tumor-bearing mice in vivo. We first analyzed the radioactive uptake of positron emission tomography (PET) tracers in BAT of CT26 xenograft mice with 18F-fluorodeoxyglucose ([¹⁸F]FDG) and [¹⁸F]DPA714. We also studied the BAT uptake of [¹⁸F]DPA714 in CT26, A549 and LLC tumor models. The dynamic distribution of [¹⁸F]FDG is quite var

SUBMITTER: Niu N 

PROVIDER: S-EPMC7714432 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature